Research Articles
Metabolic Quiescence and Activation: A Comparative Analysis of Energy Regulation in Dormant Plant Seeds and Microbial Cells
This article provides a comparative analysis of energy metabolism in dormant plant seeds and microbial cells, exploring the parallel strategies of metabolic arrest and reactivation.
The VBNC State: Unlocking the Mechanisms of Extreme Antibiotic Tolerance in Dormant Bacteria
This article provides a comprehensive analysis of the Viable But Non-Culturable (VBNC) state, a critical survival mechanism in bacteria characterized by a complete loss of culturability on standard media coupled...
Overcoming Matrix Effects in VBNC Cell Detection: Strategies for Complex Samples in Biomedical Research
The detection of viable but non-culturable (VBNC) cells is critical for accurate risk assessment in clinical and pharmaceutical microbiology.
Chemical Force Microscopy: Probing Microbial Surface Properties for Drug Development and Biomedical Research
Chemical Force Microscopy (CFM) has emerged as a powerful technique in microbiological research, enabling the nanoscale mapping of chemical and physical properties of microbial surfaces under physiological conditions.
Beyond Culture: Advanced Culture-Independent Methods for Rapid Pathogen Detection in Clinical and Food Safety Applications
This article provides a comprehensive overview of culture-independent methods for pathogen detection, critically evaluating their capacity to overcome the limitations of traditional culture-based techniques.
Agent-Based Modeling of Biofilm Antibiotic Treatment: From Single-Cell Dynamics to Optimized Therapeutic Strategies
Agent-based models (ABMs) are emerging as powerful computational tools that provide unprecedented, high-resolution insights into the dynamics of bacterial biofilms and their response to antibiotic treatment.
Bacterial Persistence and Biofilm-Mediated Tolerance: Molecular Mechanisms, Therapeutic Challenges, and Emerging Strategies
This article provides a comprehensive analysis of bacterial persistence mechanisms, focusing on the critical role of biofilms in chronic and recurrent infections.
Emerging Bacterial Pathogens: Discovery, Detection, and Future Challenges in the Age of AMR
This article provides a comprehensive overview of the dynamic field of emerging bacterial pathogen discovery, tailored for researchers, scientists, and drug development professionals.
Eradicating the Persistent Threat: A Comprehensive Comparison of Modern Anti-Persister Cell Strategies
Persister cells, a dormant subpopulation of bacteria responsible for chronic infections and treatment relapse, represent a major challenge in antimicrobial therapy.
Comparative Evaluation of Biofilm Research Models: From Foundational Concepts to Translational Applications
This article provides a comprehensive comparative evaluation of contemporary biofilm matrix research models, addressing the critical needs of researchers, scientists, and drug development professionals.